{"id":9070,"date":"2017-04-26T11:37:33","date_gmt":"2017-04-26T15:37:33","guid":{"rendered":"http:\/\/miamiobgyn.co\/?p=9070"},"modified":"2017-04-26T11:37:33","modified_gmt":"2017-04-26T15:37:33","slug":"ucla-researchers-identify-protein-prevent-tumor-growth-cervical-cancer-2","status":"publish","type":"post","link":"https:\/\/www.toplinemd.com\/miami-obgyn\/news\/ucla-researchers-identify-protein-prevent-tumor-growth-cervical-cancer-2\/","title":{"rendered":"UCLA researchers identify protein that could prevent tumor growth in cervical cancer"},"content":{"rendered":"

UCLA scientists have identified a protein that has the potential to prevent the growth of cervical cancer<\/a> cells. The discovery could lead to the development of new treatments for the deadly disease.<\/p>\n

In a five-year study using human samples and mouse models, researchers led by Dr. Eri Srivatsan, a member of the UCLA Jonsson Comprehensive Cancer Center, found that a protein known as cystatin E\/M can inhibit cellular inflammation<\/a>, which is a major contributor to the growth of cervical cancer.<\/p>\n

Typically, inflammation develops after a woman contracts the human papilloma virus from a male partner; the virus can eventually lead to the development of cervical cancer. Environmental factors such as smoking also are closely associated with the disease.<\/p>\n

The UCLA researchers discovered that cystatin E\/M prevents a protein called NFkB, which regulates inflammation, from entering the nucleus of cervical cancer cells. As a result, decreased inflammation slows tumor<\/a> cell growth.<\/p>\n

“When key inhibitory mechanisms break down, cancer<\/a> cells produce inflammation that helps fuel cancer cell growth,” said Srivatsan, who is a professor in UCLA’s department of surgery. “By identifying this protein, we have discovered a key regulator of this breakdown. This is the first time we have found that inhibition of the protein kinase by cystatin E\/M plays a regulatory role in cell inflammation.”<\/p>\n

The study is published online in the journal Molecular and Cellular Biology<\/em>.<\/p>\n

Worldwide, cervical cancer is the second most common cause of cancer-related deaths in women. In the United States, HPV<\/a> is detected in 90 percent of cervical cancer tumors and is the most common sexually transmitted disease<\/a>, Srivatsan said.<\/p>\n

Although cystatin E\/M and its basic function had previously been identified, little else was known about the protein’s molecular activity until 2008, when Srivatsan and colleagues published initial findings<\/a>.<\/p>\n

The new study built upon that research. Srivatsan’s team analyzed 20,000 genes in two sets of cell lines-one set that expressed the cystatin E\/M protein and the other set didn’t. They also analyzed 66 samples of normal and cancerous cervical tissues to determine the molecular mechanism that inhibits cancer cell growth.<\/p>\n

In future research, Srivatsan’s team will aim to determine whether cystatin E\/M could inhibit tumor cell growth in chemo-radiation-resistant breast cancers<\/a> in human tissue cultures and animal models.<\/p>\n

Dr. Neda A. Moatamed, assistant professor in the department of pathology and laboratory medicine at UCLA and a member of the UCLA Jonsson Comprehensive Cancer Center was also a co-author of the study.<\/p>\n

The research was supported by the VA Greater Los Angeles Healthcare System.<\/p>\n

Article: Cystatin E\/M suppresses tumor cell growth through cytoplasmic retention of NF-\u03baB<\/a>, Eri Srivatsan et al., Molecular and Cellular Biology<\/em>, doi: 10.1128\/MCB.00878-15, published online 18 April 2016.<\/p>\n","protected":false},"excerpt":{"rendered":"

UCLA scientists have identified a protein that has the potential to prevent the growth of cervical cancer cells. The discovery<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[15],"tags":[],"class_list":["post-9070","post","type-post","status-publish","format-standard","hentry","category-featured-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\n\t\t\n